Enzyme Catalysis

   Theory

   Contribution from Protein Conformation Transition

   Mechanisms and Free Energies of Catalysis

   Dynamics and Tunneling in Catalysis

   Illustrative Examples (an incomplete list)

   Protein Tyrosine Phosphatases

   Cathepsin K

   Phosphotriesterase (PTE)

   Alanine Racemase (Carbon Acidity)

              Alanine Racemase (Mechanism)

    Enolase

   Haloalkane Dehalogenase

              Dynamics and Mechanism

    Decarboxylases

              C&E News report on OMP Decarboxylase

   4-Oxalocrotonate Tautomerase

   Hairpin Ribozyme

   Nitroalkane Oxidase

   Dopa Decarboxylase

   Acutolysin

   Aristolochene Synthase

   Dihydrofolate Reductase (DHFR)

              Temperature dependence KIE

              Reaction Path and Mechanism

              Nature of Transition State

              KIE in Hyperthermophilic DHFR

   Squalene Cyclase

   4-Chlorobenzoyl-CoA dehalogenase

   Acyl-CoA Dehydrogenase

              Mechanism, KIE, and Reaction Path

              Redox Potential

   Liver alcohol dehydrogenase

              Tunneling

   Xylose Isomerase

   Carbonic Anhydrase

   HIV-1 Protease

Top view of ODCase beta-barrel dimer

Side view of ODCase

Electron density map at the ODCase active site